- •The long human lifespan evolved when our ancestors were homozygous for APOE ɛ4.
- •The ɛ4 allele is associated with heart disease, Alzheimer’s disease, and reduced lifespan.
- •High levels of physical activity reduce disease risks in ɛ4 carriers.
- •We propose that human longevity evolved due to a shift toward high activity levels.
- •Current lifespan constraints may reflect a mismatch between lifestyle and evolutionary history.