Resistance exercise load does not determine training-mediated hypertrophic gains in young men
In summary, we report that similar resistance training-induced muscle hypertrophy can result from lifting loads to failure with higher (80% of 1RM) and lower (30% of 1RM) loads than are currently recommended for novice lifters (1). The results from our study also suggest that additional training volume in the form of more sets may result in greater muscle hypertrophy; however, due to the inherent variability in the individual response to resistance training, it appears that longer-term training studies may be required to manifest these differences more clearly. Importantly, these data support the concept that acute increases in rates of MPS are reasonable qualitative indexes of the amount of muscle protein gain with similar training as they appear to be with nutrition. However, these gains in muscle mass may be dependent in the adequate provision of amino acids (3). Finally, despite that lack of support for the idea of a hypertrophy-specific load and repetition range, these data confirm the specificity principle of training with regard to muscle strength and endurance.