Sub-optimal sleep may activate depressive genes, increase risk for major depression

http://www.eurekalert.org/pub_releases/2014-01/aaos-sfn013114.php

A study of 1,788 adult twins is the first to demonstrate a gene by environment interaction between self-reported habitual sleep duration and depressive symptoms. Results suggest that sleep durations outside the normal range increase the genetic risk for depressive symptoms. Among twins with a normal sleep duration of seven to 8.9 hours per night, the total heritability of depressive symptoms was 27 percent. However, the genetic influence on depressive symptoms increased to 53 percent among twins with a short sleep duration of five hours per night and 49 percent among those who reported sleeping 10 hours per night.

« We were surprised that the heritability of depressive symptoms in twins with very short sleep was nearly twice the heritability in twins sleeping normal amounts of time, » said principal investigator Dr. Nathaniel Watson, associate professor of neurology and co-director of the University of Washington Medicine Sleep Center in Seattle, Wash. « Both short and excessively long sleep durations appear to activate genes related to depressive symptoms, » added Watson, who also serves on the board of directors of the American Academy of Sleep Medicine.

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